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| Catalog: | C-FC-2847A |
| Product Type: | FCM Antibody |
| Size: | 50 µL/100 µL/200 µL |
| Reactivity: | Human |
| Specificity: | Human BMP4 |
| Analysis mode: | FCM,ICC/IF |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | IgM |
| Alternate names: | bone morphogenetic protein 4 |
| Form: | Liquid |
| Shipping: | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage: | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Purification method: | Protein A |
| Conjugation: | Unconjugated |
| Immunogen: | Recombinant Human BMP-4 protein |
| Buffer: | 0.2 μm filtered solution in PBS |
| Application: | Early Mesodermal Lineage Markers; Cardiac Stem Cell Markers |
BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling.
Core Diagnostic Capabilities
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