ANO1 polyclonal antibody

Catalog:	C0548A
Product Type:	Antibody
Reactivity:	H,M
Analysis mode:	WB,IHC,ELISA
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Concentration:	0.5 mg/mL
Storage:	-20℃
Buffer:	PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method:	Antigen affinity purification
Application:	Cancer, Tags and Cell Markers
Conjugation:	Unconjugated
Immunogen:	ANO1
Swiss port:	Q5XXA6
Gene accession:	NP060513
Celluar localization:	Cell membrane, Cytoplasm
Tissue specificity:	Broadly expressed with higher levels in liver and skeletal muscle.
Column1:	TMEM16A, also known as DOG1 (Discovered on gastrointestinal stromal tumors protein 1) or ANO1 (anoctamin 1), is a 986 amino acid multi-channel membrane protein located in the cell membrane and cytoplasm. TMEM16A is expressed in a variety of tissues with the highest expression levels in skeletal muscle and liver, and its function is calcium-activated chloride channel necessary for normal tracheal development. Human TMEM16A has 90% sequence identity with mouse TMEM16A, indicating that it has a conservative effect among species. TMEM16A exists in gastrointestinal stromal tumors, breast cancer and gastric cancer, suggesting that TMEM16A plays a role in carcinogenesis.