AIM2 polyclonal antibody

The interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein that belongs to the HIN-200 family. AIM2 is believed to act as a tumor suppressor by inhibiting the transcriptional activity of NF˚B. AIM2 is located in the nucleus and contains a DAPIN domain and a HIN-200 domain. The DAPIN domain is mainly composed of a-helix, which is the domain of protein-protein interaction and can bind to other DAPIN domains. The HIN-200 domain has been shown to directly bind to DNA and bind to another protein, ASC, leading to the activation of Caspase-1.