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AF488 Anti-Mouse CD122 Antibody

  • Product Information
  • Description
Catalog: C-FC-0183A
Product Type: FCM Antibody
Size: 25μg/50μg/100μg
Reactivity: Mouse
Analysis mode: FCM
Host: Rat
Isotype: Rat IgG2a, κ
Alternate names: Interleukin-2 receptor subunit beta,Il2rb,IL-2 receptor subunit beta, IL-2R subunit beta,IL-2RB,High affinity IL-2 receptor subunit beta,p70-75,CD122
Form: Liquid
Shipping: Biological ice pack at 4℃
Storage: 2-8℃
Conjugation: AF488
Buffer: PBS with 0.05% Proclin300, 1% BSA
Swiss port: P16297
Clone NO.: 5H4
Recommended use: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results or refer to the dilution we used in the experiment.

CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit (CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.

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