Catalog: | C-FC-0004A |
Product Type: | FCM Antibody |
Size: | 50 μg/500 μg/1 mg |
Reactivity: | Human |
Analysis mode: | Depletion, FCM, IHC, IP |
Host: | Mouse |
Isotype: | Mouse IgG2b, κ |
Alternate names: | Bp35,Leukocyte surface antigen Leu-16,MS4A1,B-lymphocyte surface antigen B1 |
Form: | Liquid |
Shipping: | Biological ice pack at 4℃ |
Storage: | 2-8℃ |
Conjugation: | None (Purified antibody/Azide Free/Low endotoxin) |
Buffer: | 0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay. |
Swiss port: | P11836 |
Clone NO.: | 2H7 |
Recommended use: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 μg per 106 cells in 100 μL volume or 100 μL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.
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