ABL2 polyclonal antibody

This gene encodes a member of the Abelson family of non-receptor tyrosine protein kinases. This protein is highly similar to the c-abl oncogene 1 protein, including tyrosine kinase, SH2 and SH3 domains, and plays a role in cytoskeletal rearrangement through its c-terminal F-actin and microtubule binding sequence. This gene is expressed in normal cells and tumor cells, and is involved in the translocation of the ets variant 6 gene in leukemia. It has been found that this gene has multiple alternate splicing transcription variants that encode different protein subtypes.